Efficacy of linezolid alone or in combination with vancomycin for treatment of experimental endocarditis due to methicillin-resistant Staphylococcus aureus

Antimicrob Agents Chemother. 2003 Sep;47(9):3002-4. doi: 10.1128/AAC.47.9.3002-3004.2003.

Abstract

The levels of effectiveness of linezolid, vancomycin, and the combination of linezolid and vancomycin were compared in the rabbit model of endocarditis caused by a clinical methicillin-resistant Staphylococcus aureus (MRSA) isolate. Vancomycin alone was more effective than either linezolid alone or the combination of linezolid and vancomycin for the treatment of endocarditis due to MRSA.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetamides / therapeutic use*
  • Animals
  • Anti-Bacterial Agents / therapeutic use*
  • Aortic Valve / microbiology
  • Colony Count, Microbial
  • Drug Synergism
  • Drug Therapy, Combination
  • Endocarditis, Bacterial / drug therapy*
  • Endocarditis, Bacterial / microbiology
  • Female
  • Kidney / microbiology
  • Linezolid
  • Macrolides
  • Methicillin Resistance / genetics*
  • Oxazolidinones / therapeutic use*
  • Rabbits
  • Staphylococcal Infections / drug therapy*
  • Staphylococcal Infections / microbiology
  • Staphylococcus aureus*
  • Vancomycin / therapeutic use*

Substances

  • Acetamides
  • Anti-Bacterial Agents
  • Macrolides
  • Oxazolidinones
  • Vancomycin
  • Linezolid