Naphthoquinone derivatives and lignans from the Paraguayan crude drug "tayï pytá" (Tabebuia heptaphylla, Bignoniaceae)

Z Naturforsch C J Biosci. 2003 Jul-Aug;58(7-8):495-501. doi: 10.1515/znc-2003-7-809.


The Paraguayan crude drug "tayï pytá" is used to treat cancer, wounds and inflammation. It consist of the bark and trunkwood of Tabebuia heptaphylla (Bignoniaceae). A phytochemical study of the crude drug gave, in addition to previously described naphthoquinones and the known lignans cycloolivil and secoisolariciresinol, three new lapachenol (lapachonone)-, two naphthofuran-, a chromone and a naphthalene derivative. The structures were elucidated by means of high field NMR spectroscopy. The biological activity of the main compound lapachol and the related alpha-lapachone as well as the lignans cycloolivil and secoisolariciresinol can explain, at least in part, the effect atributed to the crude drug in Paraguayan folk medicine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antiparasitic Agents / pharmacology*
  • Bignoniaceae / chemistry*
  • Leishmania donovani
  • Lignans / chemistry*
  • Lignans / isolation & purification
  • Lignans / pharmacology*
  • Magnetic Resonance Spectroscopy
  • Models, Molecular
  • Molecular Conformation
  • Naphthoquinones / chemistry*
  • Naphthoquinones / isolation & purification
  • Naphthoquinones / pharmacology*
  • Paraguay
  • Plant Extracts / chemistry*
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology
  • Plant Stems / chemistry*
  • Plants, Medicinal / chemistry*


  • Antiparasitic Agents
  • Lignans
  • Naphthoquinones
  • Plant Extracts