ALK-ATIC fusion in urinary bladder inflammatory myofibroblastic tumor

Genes Chromosomes Cancer. 2003 Oct;38(2):187-90. doi: 10.1002/gcc.10267.


In this report, we describe an inflammatory myofibroblastic tumor (IMT) of the urinary bladder in a 46-year-old man. Tumor cells presented striking cytoplasmatic ALK immunopositivity. Cytogenetic and FISH analysis, by use of a multicolor chromosome 2 banding probe, revealed a 46,XY,der(2)(2pter-->2p23:2q35-->2q37:2p11-->2q35:2p23-->2p11:2q37-->2qter) karyotype. Subsequent FISH and RT-PCR analysis confirmed the ALK-ATIC chimeric fusion in tumor cells. This is the first evidence of a variant rearrangement involving the ATIC gene in IMT and the first cytogenetic description of an IMT originating from the urinary bladder.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anaplastic Lymphoma Kinase
  • Chromosomes, Human, Pair 2 / genetics
  • Humans
  • Inflammation / enzymology
  • Inflammation / genetics
  • Male
  • Middle Aged
  • Neoplasms, Muscle Tissue / enzymology*
  • Neoplasms, Muscle Tissue / genetics*
  • Neoplasms, Muscle Tissue / pathology
  • Nucleotide Deaminases / genetics*
  • Oncogene Proteins, Fusion / genetics*
  • Protein-Tyrosine Kinases / genetics*
  • Receptor Protein-Tyrosine Kinases
  • Urinary Bladder Neoplasms / enzymology*
  • Urinary Bladder Neoplasms / genetics*
  • Urinary Bladder Neoplasms / pathology


  • Oncogene Proteins, Fusion
  • ALK protein, human
  • Anaplastic Lymphoma Kinase
  • Protein-Tyrosine Kinases
  • Receptor Protein-Tyrosine Kinases
  • Nucleotide Deaminases
  • IMP cyclohydrolase