A simplified and comprehensive computational model to study the behavior of T cell populations in the thymus during normal maturation and in infection with mouse moloney leukemiavirus

In Vivo. 2003 May-Jun;17(3):225-8.


Based on a previously developed theory of dysregulative lymphoma pathogenesis, an advanced mathematical model was developed for simulation of thymic T cell populations and their differentiation stages. The model subsequently was tested in comparison to thymic changes in mice with Moloneyvirus infection and leukemia development. Numerical examples are given, which suggest that the model is useful to study T cell proliferation, differentiation, and may probably also be useful to simulate T cell changes in various lymphoproliferative diseases.

MeSH terms

  • Animals
  • Disease Models, Animal
  • Kinetics
  • Leukemia, Experimental / immunology*
  • Leukemia, Experimental / virology
  • Lymphocyte Activation
  • Mice
  • Moloney murine leukemia virus / pathogenicity*
  • Reference Values
  • T-Lymphocytes / immunology*
  • Thymus Gland / growth & development
  • Thymus Gland / immunology*
  • Time Factors