Cell proliferation without cyclin E-CDK2

Cell. 2003 Aug 22;114(4):398-9. doi: 10.1016/s0092-8674(03)00649-4.

Abstract

In this issue of Cell, Geng et al. report that mice can undergo embryonic development without cyclins E1 and E2. Fibroblasts derived from the double knockout embryos proliferate normally in culture. However, E type cyclins seem essential for endoreplication and exit from quiescence.

Publication types

  • Comment

MeSH terms

  • Animals
  • CDC2-CDC28 Kinases*
  • Cell Cycle / physiology*
  • Cyclin A / metabolism
  • Cyclin E / genetics
  • Cyclin E / metabolism*
  • Cyclin-Dependent Kinase 2
  • Cyclin-Dependent Kinases / genetics
  • Cyclin-Dependent Kinases / metabolism*
  • Fibroblasts / physiology
  • Humans
  • Mice
  • Mice, Knockout
  • Protein-Serine-Threonine Kinases / genetics
  • Protein-Serine-Threonine Kinases / metabolism*

Substances

  • Cyclin A
  • Cyclin E
  • Protein-Serine-Threonine Kinases
  • CDC2-CDC28 Kinases
  • CDK2 protein, human
  • Cdk2 protein, mouse
  • Cyclin-Dependent Kinase 2
  • Cyclin-Dependent Kinases