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, 13 (18), 2961-6

Cyclin-dependent Kinase 4 Inhibitors as a Treatment for Cancer. Part 2: Identification and Optimisation of Substituted 2,4-bis Anilino Pyrimidines

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Cyclin-dependent Kinase 4 Inhibitors as a Treatment for Cancer. Part 2: Identification and Optimisation of Substituted 2,4-bis Anilino Pyrimidines

Gloria A Breault et al. Bioorg Med Chem Lett.

Abstract

Through chemical modification and X-ray crystallography we identified the 2,4-bis anilino pyrimidines as potent inhibitors of CDK4. Herein, we describe the optimisation of this series.

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