Role of SGT1 in the regulation of plant R gene signalling

Microbes Infect. 2003 Sep;5(11):969-76. doi: 10.1016/s1286-4579(03)00183-7.


Recent important discoveries in several laboratories have identified SGT1 as an essential component of R gene-mediated disease resistance in plants. The precise molecular function of SGT1 remains unknown, although sequence analysis and structural predictions reveal that SGT1 has features of co-chaperones that associate with HSP90 in animals. This review will describe the role of SGT1 in R gene-mediated plant defence and discuss how SGT1 may regulate this process.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Arabidopsis Proteins / physiology*
  • Carrier Proteins
  • Cell Cycle Proteins / physiology*
  • Gene Expression Regulation, Plant*
  • Immunity, Innate / genetics*
  • Plant Diseases / genetics
  • Plant Diseases / microbiology
  • Plant Proteins / genetics*
  • Plant Proteins / immunology
  • Plant Proteins / metabolism
  • Plant Viruses
  • Signal Transduction*


  • Arabidopsis Proteins
  • Carrier Proteins
  • Cell Cycle Proteins
  • Plant Proteins
  • SGT1a protein, Arabidopsis