Adaptation of Candida albicans to the host environment: the role of morphogenesis in virulence and survival in mammalian hosts

Curr Opin Microbiol. 2003 Aug;6(4):338-43. doi: 10.1016/s1369-5274(03)00081-x.


Although morphological flexibility could be a key contributor to fungal virulence, no molecular data has unambiguously established fungal morphogenesis as a virulence factor for Candida albicans, nor can specific forms of Candida be regarded as absolutely indicative of saprophytism or infection at a given site on the host. The fitness of the fungus in vivo probably reflects its adaptation to the variety of microenvironments in which this opportunist must survive.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptation, Physiological / immunology
  • Animals
  • Candida albicans / growth & development*
  • Candida albicans / pathogenicity*
  • Candidiasis / immunology*
  • Candidiasis / microbiology*
  • Host-Parasite Interactions / immunology
  • Humans
  • Mammals
  • Virulence