Host-parasite interactions and trypanosome morphogenesis: a flagellar pocketful of goodies

Curr Opin Microbiol. 2003 Aug;6(4):365-70. doi: 10.1016/s1369-5274(03)00092-4.


Trypanosomes are characterised by the possession of a single flagellum and a subpellicular microtubule cytoskeleton. The flagellum is more than an organelle for motility; its position and polarity along with the sub-pellicular cytoskeleton enables the morphogenesis of a distinct flagellar pocket and the flagellar basal body is responsible for positioning and segregating the kinetoplast--the mitochondrial genome. Recent work has highlighted the molecules and morphogenesis of these cytoskeletal/flagellum structures and how dynamic events, occurring in the flagellar pocket and kinetoplast, are critical for host-parasite interactions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Flagella / physiology*
  • Host-Parasite Interactions / physiology*
  • Humans
  • Trypanosoma brucei brucei / pathogenicity*
  • Trypanosoma brucei brucei / ultrastructure
  • Trypanosomiasis, African / physiopathology*
  • Virulence