Beta-secretase (BACE) and GSK-3 mRNA levels in Alzheimer's disease

Brain Res Mol Brain Res. 2003 Aug 19;116(1-2):155-8. doi: 10.1016/s0169-328x(03)00233-x.

Abstract

Beta-secretase (BACE) and glycogen synthase kinase (GSK 3) are two enzymes thought to play a role in Alzheimer's disease. We extracted mRNA from 90 Alzheimer and 81 control brains. Levels of mRNA were quantified for BACE and GSK 3 with TaqMan real-time RT-PCR. We found no change in the Alzheimer's disease brains relative to controls for either the BACE or the GSK 3alpha mRNA levels.

Publication types

  • Comparative Study

MeSH terms

  • Alzheimer Disease / enzymology*
  • Alzheimer Disease / genetics
  • Alzheimer Disease / metabolism
  • Amyloid Precursor Protein Secretases
  • Amyloid beta-Protein Precursor / analysis
  • Amyloid beta-Protein Precursor / genetics
  • Aspartic Acid Endopeptidases
  • Endopeptidases / genetics
  • Endopeptidases / metabolism*
  • Female
  • Glial Fibrillary Acidic Protein / analysis
  • Glial Fibrillary Acidic Protein / genetics
  • Glycogen Synthase Kinase 3 / genetics
  • Glycogen Synthase Kinase 3 / metabolism*
  • Humans
  • Male
  • Microtubule-Associated Proteins / analysis
  • Microtubule-Associated Proteins / genetics
  • Phosphopyruvate Hydratase / analysis
  • Phosphopyruvate Hydratase / genetics
  • RNA, Messenger / analysis
  • RNA, Messenger / biosynthesis
  • Reverse Transcriptase Polymerase Chain Reaction / methods
  • Sex Characteristics

Substances

  • Amyloid beta-Protein Precursor
  • Glial Fibrillary Acidic Protein
  • Microtubule-Associated Proteins
  • RNA, Messenger
  • Glycogen Synthase Kinase 3
  • Amyloid Precursor Protein Secretases
  • Endopeptidases
  • Aspartic Acid Endopeptidases
  • BACE1 protein, human
  • Phosphopyruvate Hydratase