IL-10 subfamily members: IL-19, IL-20, IL-22, IL-24 and IL-26

Immunol Lett. 2003 Sep 8;88(3):171-4. doi: 10.1016/s0165-2478(03)00087-7.


It has been reported that the CD4+ T cell is a very important source of interleukin 10 (IL-10), while CD8+ cells produce low amounts. IL-10 exerts several immune stimulating, as well as inhibitory effects. There are at least five novel human IL-10 family-related molecules: IL-19, IL-20, IL-22, IL-24, and IL-26. Activated T cells produce IL-19, IL-22 and IL-26, while IL-24 is produced by activated monocytes and T-cells. IL-20 induces cheratin proliferation and Stat-3 signal transduction pathway, while IL-22 induces acute-phase production by hepatocytes and neonatal lethality with skin abnormalities reminiscent of psoriasic lesions in humans. In addition, IL-22 mediates inflammation and binds class II cytokine receptor heterodimers IL-22 RA1/CRF2-4. This cytokine is also involved in immuno-regulatory responses. IL-26 (AK155) is a novel cytokine generated by memory cells and is involved in the transformed phenotype of human T cells after infection by herpes virus. All these new IL-10 subfamily member cytokines are strongly involved in immune regulation and inflammatory responses.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Immunologic Memory
  • Interleukin-10 / genetics
  • Interleukin-10 / immunology*
  • Interleukin-10 / metabolism
  • Interleukins / genetics
  • Interleukins / immunology*
  • Interleukins / metabolism*
  • Receptors, Cytokine / immunology
  • T-Lymphocytes / immunology


  • Interleukins
  • Receptors, Cytokine
  • Interleukin-10