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Review
, 4 (9), 835-42

Similarities and Differences in CD4+ and CD8+ Effector and Memory T Cell Generation

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Review

Similarities and Differences in CD4+ and CD8+ Effector and Memory T Cell Generation

Robert A Seder et al. Nat Immunol.

Abstract

Naive CD4+ and CD8+ T cells undergo unique developmental programs after activation, resulting in the generation of effector and long-lived memory T cells. Recent evidence indicates that both cell-intrinsic and cell-extrinsic factors regulate memory T cell differentiation. This review compares and contrasts how naive CD4+ and CD8+ T cells make the transition to effector and/or memory cells and discusses the implications of these findings for vaccine development.

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