Similarities and differences in CD4+ and CD8+ effector and memory T cell generation

Nat Immunol. 2003 Sep;4(9):835-42. doi: 10.1038/ni969.


Naive CD4+ and CD8+ T cells undergo unique developmental programs after activation, resulting in the generation of effector and long-lived memory T cells. Recent evidence indicates that both cell-intrinsic and cell-extrinsic factors regulate memory T cell differentiation. This review compares and contrasts how naive CD4+ and CD8+ T cells make the transition to effector and/or memory cells and discusses the implications of these findings for vaccine development.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Animals
  • Apoptosis / immunology
  • CD4-Positive T-Lymphocytes / cytology
  • CD4-Positive T-Lymphocytes / immunology*
  • Cell Differentiation / immunology
  • Humans
  • Immunologic Memory / immunology*
  • Lymphocyte Activation / immunology
  • T-Lymphocytes, Regulatory / immunology*