Anaplastic (pleomorphic) subtype embryonal rhabdomyosarcoma of the cervix

Arch Gynecol Obstet. 2004 Dec;270(4):278-80. doi: 10.1007/s00404-003-0504-y. Epub 2003 Aug 26.


Introduction: Embryonal rhabdomyosarcoma (RMS) of the female genital tract usually occurs in the vagina during childhood. In rare cases, RMS can originate in the uterine cervix, with an incidence peak in the second decade. Recent studies have suggested that it is possible to limit surgery to local excision in stage I cases.

Case report: We present the case of a 13-year-old girl diagnosed with an anaplastic (pleomorphic) subtype embryonal RMS of the endocervix, who was treated successfully with polypectomy followed by ifosfamide-vincristine-actinomycin combination chemotherapy and brachytherapy. The patient exhibits no evidence of recurrence and has normal menstrual function 36 months following initial diagnosis.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Antibiotics, Antineoplastic / administration & dosage
  • Antineoplastic Agents, Alkylating / administration & dosage
  • Antineoplastic Agents, Phytogenic / administration & dosage
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Brachytherapy*
  • Chemotherapy, Adjuvant*
  • Dactinomycin / administration & dosage
  • Female
  • Gynecologic Surgical Procedures*
  • Humans
  • Ifosfamide / administration & dosage
  • Rhabdomyosarcoma, Embryonal / pathology
  • Rhabdomyosarcoma, Embryonal / therapy*
  • Treatment Outcome
  • Uterine Cervical Neoplasms / pathology
  • Uterine Cervical Neoplasms / therapy*
  • Vincristine / administration & dosage


  • Antibiotics, Antineoplastic
  • Antineoplastic Agents, Alkylating
  • Antineoplastic Agents, Phytogenic
  • Dactinomycin
  • Vincristine
  • Ifosfamide