[Comparative genome analysis of Helicobacter pylori strains]

Mol Biol (Mosk). 2003 Jul-Aug;37(4):625-33.
[Article in Russian]

Abstract

DNA macroarrays were used to characterize 17 Helicobacter pylori strains isolated in four geographic regions of Russia (Moscow, St. Petersburg, Kazan, and Novosibirsk). Of all genes, 1272 (81%) proved to occur in all strains and to constitute a functional core of the genome, and 293 (18.7%) were strain-specific and greatly varied among the H. pylori strains. Most (71%) of the latter had unknown functions; the remainder included restriction-modification genes (3-9%), transposition genes (2-4%), and genes coding for outer membrane proteins (2-4%). The Russian H. pylori strains did not differ in genome organization or in the number and distribution of strain-specific genes from strains isolated in other countries.

Publication types

  • Comparative Study

MeSH terms

  • Bacterial Proteins / genetics
  • Gene Order
  • Genes, Bacterial
  • Genetic Variation*
  • Genome, Bacterial*
  • Helicobacter pylori / genetics*
  • Helicobacter pylori / pathogenicity
  • Membrane Glycoproteins / genetics
  • Multigene Family
  • Oligonucleotide Array Sequence Analysis
  • Open Reading Frames
  • Russia
  • Species Specificity
  • Virulence / genetics

Substances

  • Bacterial Proteins
  • Membrane Glycoproteins
  • VapD protein, Bacteria