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, 40 (12), 3181-4

Repandiol, a New Cytotoxic Diepoxide From the Mushrooms Hydnum Repandum and H. Repandum Var. Album

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Repandiol, a New Cytotoxic Diepoxide From the Mushrooms Hydnum Repandum and H. Repandum Var. Album

A Takahashi et al. Chem Pharm Bull (Tokyo).

Abstract

Repandiol, a new cytotoxic diepoxide has been isolated from the mushrooms Hydnum repandum and H. repandum var. album. The chemical structure was elucidated as (2R,3R,8R,9R)-4,6-decadiyne-2,3:8,9-diepoxy-1,10-diol on the basis of spectroscopic analysis. The structure was confirmed by the synthesis of optically active repandiol. Repandiol displayed potent cytotoxic activity against various tumor cells.

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