Abstract
A new cytotoxic substance, designated russuphelin A (1), has been isolated from the mushroom Russula subnigricans Hongo (Basidiomycetes). The structure was elucidated as 2,6-bis(2,6-dichloro-4-hydroxyphenyloxy)-1,4-dimethoxy-benzene on the basis of spectroscopic data and confirmed by total synthesis.
MeSH terms
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Animals
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Anisoles / isolation & purification*
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Anisoles / toxicity
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / toxicity
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Basidiomycota / chemistry*
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Cell Line
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Cell Survival / drug effects
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Chlorophenols / isolation & purification*
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Chlorophenols / toxicity
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Cytotoxins / chemical synthesis
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Cytotoxins / isolation & purification*
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Cytotoxins / toxicity
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Drug Screening Assays, Antitumor
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Humans
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Tumor Cells, Cultured
Substances
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Anisoles
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Antineoplastic Agents
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Chlorophenols
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Cytotoxins
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russuphelin A