Russuphelin A, a new cytotoxic substance from the mushroom Russula subnigricans Hongo

Chem Pharm Bull (Tokyo). 1992 Dec;40(12):3185-8. doi: 10.1248/cpb.40.3185.

Abstract

A new cytotoxic substance, designated russuphelin A (1), has been isolated from the mushroom Russula subnigricans Hongo (Basidiomycetes). The structure was elucidated as 2,6-bis(2,6-dichloro-4-hydroxyphenyloxy)-1,4-dimethoxy-benzene on the basis of spectroscopic data and confirmed by total synthesis.

MeSH terms

  • Animals
  • Anisoles / isolation & purification*
  • Anisoles / toxicity
  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / toxicity
  • Basidiomycota / chemistry*
  • Cell Line
  • Cell Survival / drug effects
  • Chlorophenols / isolation & purification*
  • Chlorophenols / toxicity
  • Cytotoxins / chemical synthesis
  • Cytotoxins / isolation & purification*
  • Cytotoxins / toxicity
  • Drug Screening Assays, Antitumor
  • Humans
  • Tumor Cells, Cultured

Substances

  • Anisoles
  • Antineoplastic Agents
  • Chlorophenols
  • Cytotoxins
  • russuphelin A