Synthesis and cytotoxic evaluation of novel thiazolocarbazoles. Part III

J Enzyme Inhib Med Chem. 2003 Apr;18(2):167-74. doi: 10.1080/1475636032000069837.

Abstract

Novel thiazolocarbazole derivatives have been synthesized via the corresponding imino-1,2,3-dithiazoles. In vitro antitumor activity of these polyheterocyclic compounds was studied.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents* / chemical synthesis
  • Antineoplastic Agents* / chemistry
  • Antineoplastic Agents* / pharmacology
  • Carbazoles* / chemical synthesis
  • Carbazoles* / chemistry
  • Carbazoles* / pharmacology
  • Cell Division / drug effects
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Inhibitory Concentration 50
  • Leukemia L1210 / pathology
  • Mice
  • Molecular Structure
  • Structure-Activity Relationship
  • Thiazoles* / chemical synthesis
  • Thiazoles* / chemistry
  • Thiazoles* / pharmacology

Substances

  • Antineoplastic Agents
  • Carbazoles
  • Thiazoles