Abstract
Oral administration of spirobishexahydropyrimidine showed an increase in the activity of serum transaminases, lactate dehydrogenase and alkaline phosphatase. Biological half life and other pharmacokinetic parameters showed rapid absorption and slow elimination of the drug.
MeSH terms
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Alanine Transaminase / blood*
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Alkaline Phosphatase / blood*
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Animals
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Aspartate Aminotransferases / blood*
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Kinetics
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L-Lactate Dehydrogenase / blood*
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Pyrimidines / pharmacokinetics
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Pyrimidines / pharmacology*
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Rabbits
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Spiro Compounds / pharmacokinetics
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Spiro Compounds / pharmacology*
Substances
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Pyrimidines
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Spiro Compounds
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spirobishexahydropyrimidine
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L-Lactate Dehydrogenase
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Aspartate Aminotransferases
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Alanine Transaminase
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Alkaline Phosphatase