c-Myc recruits P-TEFb for transcription, cellular proliferation and apoptosis

Oncogene. 2003 Aug 28;22(36):5707-11. doi: 10.1038/sj.onc.1206800.

Abstract

c-Myc promotes cellular proliferation, sensitizes cells to apoptosis and prevents differentiation. It binds cyclin T1 structurally and functionally from the positive transcription elongation factor b (P-TEFb). The cyclin-dependent kinase 9 (Cdk9) in P-TEFb then phosporylates the C-terminal domain of RNA polymerase II, which is required for the transition from initiation to elongation of eukaryotic transcription. Inhibiting P-TEFb blocks the transcription of its target genes as well as cellular proliferation and apoptosis induced by c-Myc.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apoptosis*
  • COS Cells
  • Cell Division
  • Genes, myc / physiology*
  • Positive Transcriptional Elongation Factor B
  • Protein-Serine-Threonine Kinases / physiology*
  • Transcription, Genetic*

Substances

  • Positive Transcriptional Elongation Factor B
  • Protein-Serine-Threonine Kinases