No effect of garlic extract supplement on serum lipid levels in hypercholesterolemic subjects

J Med Assoc Thai. 2003 Aug;86(8):750-7.


Objective: The authors assessed the effects of an enteric-coated Thai garlic extract tablet standardized for allicin-releasing potential on serum lipid levels in hypercholesterolemic subjects.

Subjects and method: The authors performed a randomized, double-blind, placebo-controlled trial in 136 hypercholesterolemic subjects (cholesterol concentrations > or = 5.2 mmol/L; mean age +/- SD: 47.0 +/- 6.6 yr). All subjects were given dietary advice to lower fat intake within 4 weeks and were advised to eat normally during the study period. The subjects were randomly assigned to receive an enteric-coated Thai garlic extract tablet once daily (standardized to 1.12% allicin or 5.6 mg/tablet), or placebo after the evening meal for 12 weeks. Seventy subjects (32.9% male; mean age +/- SD and BMI of 47.0 +/- 6.6 yr and 24.6 +/- 3.3 kg/m2) received the garlic extract treatment while 66 subjects (37.9% male, mean age +/- SD and BMI of 47.0 +/- 6.0 yr and 24.3 +/- 3.4 kg/m2) received placebo.

Results: There were no statistically significant changes in serum total cholesterol, triglycerides, low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol after the 12-week treatment as analyzed on repeated measures by analysis of variance. In addition, no changes in plasma glucose, liver and renal functions were found.

Conclusions: Treatment with an enteric garlic-coated Thai garlic extract and dietary advice did not produce any significant changes in lipid levels in subjects with hypercholesterolemia.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cholesterol, HDL / blood
  • Cholesterol, LDL / blood
  • Disulfides
  • Double-Blind Method
  • Female
  • Humans
  • Hypercholesterolemia / blood*
  • Hypercholesterolemia / therapy*
  • Hypolipidemic Agents / pharmacology*
  • Lipids / blood*
  • Male
  • Middle Aged
  • Sulfinic Acids / administration & dosage
  • Sulfinic Acids / pharmacology*
  • Triglycerides / blood


  • Cholesterol, HDL
  • Cholesterol, LDL
  • Disulfides
  • Hypolipidemic Agents
  • Lipids
  • Sulfinic Acids
  • Triglycerides
  • allicin