People Thinking About Thinking People. The Role of the Temporo-Parietal Junction in "Theory of Mind"

Neuroimage. 2003 Aug;19(4):1835-42. doi: 10.1016/s1053-8119(03)00230-1.

Abstract

Humans powerfully and flexibly interpret the behaviour of other people based on an understanding of their minds: that is, we use a "theory of mind." In this study we distinguish theory of mind, which represents another person's mental states, from a representation of the simple presence of another person per se. The studies reported here establish for the first time that a region in the human temporo-parietal junction (here called the TPJ-M) is involved specifically in reasoning about the contents of another person's mind. First, the TPJ-M was doubly dissociated from the nearby extrastriate body area (EBA; Downing et al., 2001). Second, the TPJ-M does not respond to false representations in non-social control stories. Third, the BOLD response in the TPJ-M bilaterally was higher when subjects read stories about a character's mental states, compared with stories that described people in physical detail, which did not differ from stories about nonhuman objects. Thus, the role of the TPJ-M in understanding other people appears to be specific to reasoning about the content of mental states.

MeSH terms

  • Awareness / physiology*
  • Brain Mapping
  • Dominance, Cerebral / physiology
  • Facial Expression
  • Humans
  • Image Enhancement*
  • Image Processing, Computer-Assisted*
  • Interpersonal Relations*
  • Magnetic Resonance Imaging*
  • Nerve Net / physiology*
  • Oxygen / blood*
  • Parietal Lobe / physiology*
  • Pattern Recognition, Visual / physiology
  • Problem Solving / physiology
  • Social Perception*
  • Speech Perception
  • Temporal Lobe / physiology*
  • Thinking / physiology*
  • Visual Cortex / physiology

Substances

  • Oxygen