The Versatile Beta-Barrel Membrane Protein

Curr Opin Struct Biol. 2003 Aug;13(4):404-11. doi: 10.1016/s0959-440x(03)00099-x.

Abstract

The beta-barrel membrane protein is found in the outer membranes of bacteria, mitochondria and chloroplasts. Approximately 2-3% of the genes in Gram-negative bacterial genomes encode beta-barrels. Whereas there are fewer than 20 known three-dimensional beta-barrel structures, genomic databases currently contain thousands of beta-barrels belonging to dozens of families. New research is revealing the variety of beta-barrel structures and the variety of functions performed by these versatile proteins.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Bacterial Outer Membrane Proteins / chemistry
  • Bacterial Outer Membrane Proteins / physiology
  • Chloroplasts / chemistry*
  • Chloroplasts / physiology*
  • Escherichia coli Proteins / chemistry
  • Escherichia coli Proteins / physiology
  • Gram-Negative Bacteria / chemistry*
  • Gram-Negative Bacteria / physiology*
  • Hydrolases*
  • Membrane Proteins / chemistry*
  • Membrane Proteins / physiology*
  • Mitochondria / chemistry*
  • Mitochondria / physiology*
  • Porins
  • Protein Structure, Tertiary
  • Receptors, Virus / chemistry
  • Receptors, Virus / physiology

Substances

  • Bacterial Outer Membrane Proteins
  • Escherichia coli Proteins
  • Membrane Proteins
  • Porins
  • Receptors, Virus
  • maltoporins
  • OmpX protein, E coli
  • Hydrolases