Cardiovascular autonomic dysfunction in primary Sjögren's syndrome

Rheumatology (Oxford). 2004 Jan;43(1):95-9. doi: 10.1093/rheumatology/keg468. Epub 2003 Aug 29.


Objective: To assess the occurrence and clinical significance of a cardiovascular autonomic nervous system dysfunction in primary Sjögren's syndrome (pSS).

Methods: Fifty-one pSS patients participated in this case-control study. Heart rate and blood pressure variability measurements, spontaneous baroreflex sensitivity examinations and cardiovascular reflex tests were performed.

Results: The results of the heart rate and blood pressure variability measurements and also the baroreflex sensitivity parameters of the pSS patients peaked in the lowest percentile ranges of a database on 559 healthy control subjects (P < 0.05). In three of the five cardiovascular reflex tests, the frequencies of abnormal results were significantly higher among the patients than among the controls (P < 0.05), and the median autonomic neuropathy score was also elevated (3 vs 0 in the controls; P < 0.0001).

Conclusion: Signs of an autonomic nervous system dysfunction involving the cardiovascular system can be discerned in the majority of pSS patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Autonomic Nervous System Diseases / complications*
  • Autonomic Nervous System Diseases / physiopathology
  • Baroreflex
  • Blood Pressure
  • Cardiovascular System / physiopathology
  • Case-Control Studies
  • Chi-Square Distribution
  • Databases, Factual
  • Female
  • Heart Rate
  • Humans
  • Male
  • Middle Aged
  • Sensory Thresholds
  • Sjogren's Syndrome / complications*
  • Sjogren's Syndrome / physiopathology
  • Statistics, Nonparametric