The regulation of immunoglobulin E class-switch recombination

Nat Rev Immunol. 2003 Sep;3(9):721-32. doi: 10.1038/nri1181.


Immunoglobulin E (IgE) isotype antibodies are associated with atopic disease, namely allergic rhinitis, asthma and atopic dermatitis, but are also involved in host immune defence mechanisms against parasitic infection. The commitment of a B cell to isotype class switch to an IgE-producing cell is a tightly regulated process, and our understanding of the regulation of IgE-antibody production is central to the prevention and treatment of atopic disease. Both those that are presently in use and potential future therapies to prevent IgE-mediated disease take advantage of our existing knowledge of the specific mechanisms that are required for IgE class switching.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Humans
  • Immunoglobulin Class Switching / genetics
  • Immunoglobulin Class Switching / immunology*
  • Immunoglobulin E / biosynthesis
  • Immunoglobulin E / genetics
  • Immunoglobulin E / immunology*
  • Immunoglobulin Isotypes / genetics
  • Immunoglobulin Isotypes / immunology*
  • Mice


  • Immunoglobulin Isotypes
  • Immunoglobulin E