Are follicular dendritic cells really good for nothing?

Nat Rev Immunol. 2003 Sep;3(9):764-9. doi: 10.1038/nri1179.


Follicular dendritic cells (FDCs), which reside in the primary B-cell follicles and germinal centres of lymphoid tissues, can sequester antigen in the form of immune complexes and are thought to be pivotal to the germinal-centre reaction and the maintenance of immunological memory. But, many recent studies question the importance of FDCs and their bound immune complexes in B-cell responses. This article asks whether we can truly rule out a requirement for these cells in host defence.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigen-Antibody Complex / immunology
  • Apoptosis / immunology
  • B-Lymphocytes / cytology
  • B-Lymphocytes / immunology
  • Dendritic Cells, Follicular / cytology
  • Dendritic Cells, Follicular / immunology*
  • Germinal Center / cytology
  • Germinal Center / immunology
  • Humans
  • Immunologic Memory / immunology
  • Receptors, Antigen, B-Cell / immunology


  • Antigen-Antibody Complex
  • Receptors, Antigen, B-Cell