Leukotriene B4 receptor BLT1 mediates early effector T cell recruitment

Nat Immunol. 2003 Oct;4(10):982-90. doi: 10.1038/ni970. Epub 2003 Aug 31.


Leukotriene B4 (LTB4) was originally described as a potent lipid myeloid cell chemoattractant, rapidly generated from innate immune cells, that activates leukocytes through the G protein-coupled receptor BLT1. We report here that BLT1 is expressed on effector CD4+ T cells generated in vitro as well as in vivo when effector T cells migrate out of the lymphoid compartment and are recruited into peripheral tissues. BLT1 mediated LTB4-induced T helper type 1 (T(H)1) and T(H)2 cell chemotaxis and firm adhesion to endothelial cells under flow, as well as early CD4+ and CD8+ T cell recruitment into the airway in an asthma model. Our findings show that the LTB4-BLT1 pathway is involved in linking early immune system activation and early effector T cell recruitment.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Asthma / immunology*
  • Bronchoalveolar Lavage Fluid / cytology
  • CD4-Positive T-Lymphocytes / immunology*
  • Chemotaxis, Leukocyte / immunology
  • Disease Models, Animal
  • Female
  • Flow Cytometry
  • Immunoglobulin E / immunology
  • Immunoglobulin G / immunology
  • Leukotriene B4 / immunology*
  • Lymphocyte Activation / immunology
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Receptors, Leukotriene B4 / immunology*
  • T-Lymphocyte Subsets / immunology


  • Immunoglobulin G
  • Receptors, Leukotriene B4
  • Leukotriene B4
  • Immunoglobulin E