Mast cell-dependent migration of effector CD8+ T cells through production of leukotriene B4

Nat Immunol. 2003 Oct;4(10):974-81. doi: 10.1038/ni971. Epub 2003 Aug 31.


Studies in both humans and rodents indicate that CD8+ T cells may be important in allergic inflammation. However, neither the mechanisms that mediate CD8+ T cell recruitment to inflamed tissues nor the relative participation of effector and central memory CD8+ T cells is known. Here we report that activated mast cells induced chemotaxis of effector, but not central memory, CD8+ T cells through production of leukotriene B4 (LTB4). These studies indicate that LTB4 production by activated peripheral leukocytes could be important for the recruitment of effector CD8+ T cells to sites of inflammation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Base Sequence
  • Chemotaxis, Leukocyte / immunology*
  • Female
  • Hyaluronan Receptors / genetics
  • Hyaluronan Receptors / immunology
  • Leukotriene B4 / biosynthesis
  • Leukotriene B4 / immunology*
  • Male
  • Mast Cells / immunology*
  • Mast Cells / metabolism
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Molecular Sequence Data
  • Oligonucleotide Array Sequence Analysis
  • Receptors, CCR5 / genetics
  • Receptors, CCR5 / immunology
  • Receptors, Interleukin-2 / genetics
  • Receptors, Interleukin-2 / immunology
  • Receptors, Leukotriene B4 / immunology*
  • T-Lymphocyte Subsets / immunology
  • T-Lymphocytes, Regulatory / immunology*


  • Hyaluronan Receptors
  • Receptors, CCR5
  • Receptors, Interleukin-2
  • Receptors, Leukotriene B4
  • Leukotriene B4

Associated data

  • GENBANK/AF044030