The application of bone morphogenetic proteins to dental tissue engineering

Nat Biotechnol. 2003 Sep;21(9):1025-32. doi: 10.1038/nbt864.


Progress in understanding the role of bone morphogenetic proteins (BMPs) in craniofacial and tooth development, the demonstration of stem cells in dental pulp and accumulating knowledge on biomaterial scaffolds have set the stage for tissue engineering and regenerative therapy of the craniofacial complex. Furthermore, the recent approval by the US Food and Drug Administration (FDA; Rockville, MD, USA) of recombinant human BMPs for accelerating bone fusion in slow-healing fractures indicates that this protein family may prove useful in designing regenerative treatments in dental applications. In the near term, these advances are likely to be applied to endodontics and periodontal surgery; ultimately, they may facilitate approaches to regenerating whole teeth for use in tooth replacement.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Bone Morphogenetic Proteins / physiology*
  • Bone Regeneration / physiology*
  • Dental Implants*
  • Endodontics / methods
  • Extracellular Matrix / physiology
  • Guided Tissue Regeneration, Periodontal / methods*
  • Humans
  • Periodontics / methods
  • Recombinant Proteins
  • Signal Transduction / physiology
  • Stem Cell Transplantation / methods*
  • Tissue Engineering / methods*
  • Tooth / growth & development*
  • Wound Healing / physiology*


  • Bone Morphogenetic Proteins
  • Dental Implants
  • Recombinant Proteins