Open pilot study of gabapentin versus trazodone to treat insomnia in alcoholic outpatients

Psychiatry Clin Neurosci. 2003 Oct;57(5):542-4. doi: 10.1046/j.1440-1819.2003.01161.x.

Abstract

Alcohol-dependent outpatients with persisting insomnia were treated with either gabapentin or trazodone. Patients were assessed at baseline and after 4-6 weeks on medication using the Sleep Problems Questionnaire (SPQ). Of 55 cases initially treated, 9% dropped out due to morning drowsiness. Of the remaining 50 cases, 34 were treated with gabapentin (mean dose +/- SD = 888 +/- 418 mg) at bedtime and 16 were treated with trazodone (105 +/- 57 mg) at bedtime. Both groups improved significantly on the SPQ but the gabapentin group improved significantly more than the trazodone group. Controlled studies are warranted to replicate these findings.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acetates / therapeutic use*
  • Alcoholism / complications*
  • Amines*
  • Antidepressive Agents, Second-Generation / therapeutic use*
  • Cyclohexanecarboxylic Acids*
  • Female
  • Gabapentin
  • Humans
  • Male
  • Outpatients*
  • Pilot Projects
  • Sleep Initiation and Maintenance Disorders / drug therapy*
  • Sleep Initiation and Maintenance Disorders / etiology*
  • Sleep Stages / drug effects
  • Trazodone / therapeutic use*
  • gamma-Aminobutyric Acid*

Substances

  • Acetates
  • Amines
  • Antidepressive Agents, Second-Generation
  • Cyclohexanecarboxylic Acids
  • gamma-Aminobutyric Acid
  • Gabapentin
  • Trazodone