Resistin messenger-RNA expression is increased by proinflammatory cytokines in vitro

Biochem Biophys Res Commun. 2003 Sep 19;309(2):286-90. doi: 10.1016/j.bbrc.2003.07.003.


Resistin is a recently discovered polypeptide that induces insulin resistance in rodents. While in rodents resistin is predominantly expressed in adipocytes, in humans peripheral blood mononuclear cells (PBMC) seem to a be a major source of resistin. In the present study, we show that in human PBMC resistin mRNA expression-determined by fluorescence-based real-time polymerase chain reaction-is strongly increased by the proinflammatory cytokines interleukin (IL)-1, IL-6, tumor necrosis factor alpha (TNF-alpha), and also by lipopolysaccharides (LPS), respectively, while no effect was found by interferon-gamma (IFN-gamma) or leptin. Our results suggest that in humans resistin may be a link in the well-known association between inflammation and insulin resistance.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chemokines / pharmacology*
  • Cytokines / pharmacology
  • Dose-Response Relationship, Drug
  • Gene Expression Regulation / drug effects*
  • Hormones, Ectopic / biosynthesis*
  • Hormones, Ectopic / genetics
  • Humans
  • Inflammation / metabolism
  • Insulin Resistance
  • Intercellular Signaling Peptides and Proteins*
  • Leukocytes, Mononuclear / drug effects*
  • Leukocytes, Mononuclear / metabolism*
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Resistin


  • Chemokines
  • Cytokines
  • Hormones, Ectopic
  • Intercellular Signaling Peptides and Proteins
  • RETN protein, human
  • RETNLB protein, human
  • RNA, Messenger
  • Resistin