Mathematical multi-locus approaches to localizing complex human trait genes

Nat Rev Genet. 2003 Sep;4(9):701-9. doi: 10.1038/nrg1155.


Statistical analysis methods for gene mapping originated in counting recombinant and non-recombinant offspring, but have now progressed to sophisticated approaches for the mapping of complex trait genes. Here, we outline new statistical methods that capture the simultaneous effects of multiple gene loci and thereby achieve a more global view of gene action and interaction than is possible by traditional gene-by-gene analysis. We aim to show that the work of statisticians goes far beyond the running of computer programs.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Biometry
  • Chromosome Mapping / methods*
  • Chromosome Mapping / statistics & numerical data
  • Genetic Markers
  • Genotype
  • Humans
  • Linkage Disequilibrium
  • Lod Score
  • Mathematics
  • Models, Genetic*
  • Phenotype
  • Polymorphism, Single Nucleotide
  • Software Design


  • Genetic Markers