Origins of chromosome translocations in childhood leukaemia

Nat Rev Cancer. 2003 Sep;3(9):639-49. doi: 10.1038/nrc1164.


Chromosome translocations are often early or initiating events in leukaemogenesis, occurring prenatally in most cases of childhood leukaemia. Although these genetic changes are necessary, they are usually not sufficient to cause leukaemia. How, when and where do translocations arise? And can these insights aid our understanding of the natural history, pathogenesis and causes of leukaemia?

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Child
  • Fetal Diseases / embryology
  • Hematopoiesis / genetics*
  • Humans
  • Leukemia / etiology
  • Leukemia / genetics*
  • Leukemia / physiopathology
  • Translocation, Genetic / genetics*