It is a review of long-term investigations in the field of treating chronic enterocolitis in children admitted to Pyatigorsk sanatoria. The disease is proposed to be managed with different therapeutic factors: sinusoidal currents, mud, radon, oral mineral water. Such combination proved beneficial as it corrected the principal pathogenetic mechanisms of chronic enterocolitis: inflammation, dysbacteriosis, malabsorption syndrome, enzymatic defects, etc.