Secondary minimal change disease

Nephrol Dial Transplant. 2003 Aug;18 Suppl 6:vi52-8. doi: 10.1093/ndt/gfg1060.


The great majority of patients identified as having a 'minimal change lesion' accompanying the nephrotic syndrome have a primary or 'idiopathic' disorder. Nevertheless, it is quite apparent that a similar or identical lesion can appear consequent to a growing number of underlying diseases; it is then known as 'secondary minimal change disease'. The predisposing conditions include neoplastic diseases, toxic or allergic reactions to drugs, infections, auto-immune disorders and other miscellaneous entities. These disorders are reviewed and catalogued in this contribution.

Publication types

  • Review

MeSH terms

  • Humans
  • Nephrosis, Lipoid / etiology*
  • Nephrosis, Lipoid / pathology
  • Nephrosis, Lipoid / therapy