Posterior capsule opacification: comparison of 3 intraocular lenses of different materials and design

J Cataract Refract Surg. 2003 Aug;29(8):1556-9. doi: 10.1016/s0886-3350(03)00342-0.


Purpose: To compare posterior capsule opacification (PCO) after cataract surgery with implantation of 3 intraocular lenses (IOLs) of different materials and design.

Setting: St. Erik's Eye Hospital, Stockholm, Sweden.

Methods: In this prospective clinical study, 180 patients had standardized phacoemulsification performed by a single surgeon and were randomized to have implantation of a heparin-surface-modified (HSM) poly(methyl methacrylate) (PMMA) IOL (809C, Pharmacia & Upjohn), a silicone IOL (SI-40NB, Allergan), or an acrylic IOL (AcrySof MA60BM, Alcon). To morphologically evaluate PCO, retroillumination photographs were obtained and analyzed using Evaluation of Posterior Capsule Opacification computer software. The neodymium:YAG (Nd:YAG) capsulotomy rate was recorded.

Results: After 2 years, the HSM PMMA IOL group had significantly more PCO than the silicone and AcrySof IOL groups; the silicone group had significantly more PCO than the AcrySof group (P<.05). The Nd:YAG capsulotomy rate was 20% in the HSM PMMA group, 22% in the silicone group, and 8% in the AcrySof group.

Conclusion: Patients with an AcrySof IOL developed significantly less PCO than those with a silicone or HSM PMMA IOL with a round-edged design.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Acrylic Resins
  • Aged
  • Aged, 80 and over
  • Cataract / etiology*
  • Coated Materials, Biocompatible
  • Female
  • Follow-Up Studies
  • Humans
  • Lens Capsule, Crystalline / pathology*
  • Lens Implantation, Intraocular / adverse effects*
  • Lenses, Intraocular / adverse effects*
  • Male
  • Middle Aged
  • Phacoemulsification / adverse effects
  • Polymethyl Methacrylate
  • Postoperative Complications*
  • Prospective Studies
  • Prosthesis Design
  • Silicone Elastomers


  • Acrylic Resins
  • Coated Materials, Biocompatible
  • Silicone Elastomers
  • Polymethyl Methacrylate