Prevalence of the mitochondrial DNA A1555G mutation in sensorineural deafness patients in island Southeast Asia

J Hum Genet. 2003;48(9):480-483. doi: 10.1007/s10038-003-0056-9. Epub 2003 Sep 3.

Abstract

A mtDNA A1555G base substitution in a highly conserved region of the 12S rRNA gene has been reported to be the main cause of aminoglycoside induced deafness. This mutation is found in approximately 3% of Japanese and 0.5-2.4% of European sensorineural deafness patients. We report a high prevalence (5.3%) of the A1555G mutation in sensorineural deafness patients in Sulawesi (Indonesia). Our result confirms the importance of determining the prevalence of the mtDNA A1555G mutation in different populations, and the need for mutation detection before the administration of aminoglycoside antibiotics.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Case-Control Studies
  • Child
  • DNA Mutational Analysis
  • DNA Primers / chemistry
  • DNA, Mitochondrial / genetics*
  • Diabetes Mellitus, Type 2 / genetics
  • Hearing Loss, Sensorineural / epidemiology
  • Hearing Loss, Sensorineural / genetics*
  • Humans
  • Indonesia / epidemiology
  • Middle Aged
  • Mitochondria / genetics
  • Mutation / genetics*
  • Pedigree
  • Phenotype
  • Polymerase Chain Reaction
  • Prevalence
  • RNA
  • RNA, Mitochondrial
  • RNA, Ribosomal / genetics*

Substances

  • DNA Primers
  • DNA, Mitochondrial
  • RNA, Mitochondrial
  • RNA, Ribosomal
  • RNA, ribosomal, 12S
  • RNA