Carbamazepine-induced systemic lupus erythematosus-like disease

Intern Med. 1992 Nov;31(11):1303-5. doi: 10.2169/internalmedicine.31.1303.


A 14-year-old female developed systemic lupus erythematosus (SLE)-like symptoms, rash, fever, leukopenia and positive anti-nuclear antibody (ANA) two weeks after administration of carbamazepine (CBZ; Tegretol) used against benign Rolandic epilepsy. Clinical symptoms and leukopenia normalized after discontinuation of CBZ and administration of prednisolone at 40 mg. The cases of CBZ-induced SLE reported in the literature were reviewed.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adolescent
  • Carbamazepine / adverse effects*
  • Epilepsy / drug therapy
  • Female
  • Humans
  • Lupus Erythematosus, Systemic / chemically induced*
  • Lupus Erythematosus, Systemic / diagnosis
  • Lupus Erythematosus, Systemic / drug therapy
  • Prednisolone / therapeutic use


  • Carbamazepine
  • Prednisolone