Inter-relationships between rheumatoid arthritis and periodontal disease. A review

J Clin Periodontol. 2003 Sep;30(9):761-72. doi: 10.1034/j.1600-051x.2003.00371.x.


This review considers the considerable similarities between periodontal disease and rheumatoid arthritis (RA). While the etiology of these two diseases may differ, the underlying pathogenic mechanisms are remarkably similar and it is possible that individuals manifesting both periodontitis and RA may suffer from a unifying underlying systemic dysregulation of the inflammatory response. In light of these findings, the implications for the use of disease-modifying medications in the management of these two chronic inflammatory conditions is apparent. Further longitudinal studies and medication-based intervention studies are required to determine just how closely these two conditions are allied.

Publication types

  • Review

MeSH terms

  • Arthritis, Rheumatoid / drug therapy
  • Arthritis, Rheumatoid / etiology*
  • Arthritis, Rheumatoid / immunology
  • Disease Progression
  • Humans
  • Periodontitis / drug therapy
  • Periodontitis / etiology*
  • Periodontitis / immunology