No association of germline alteration of MSR1 with prostate cancer risk

Nat Genet. 2003 Oct;35(2):128-9. doi: 10.1038/ng1239. Epub 2003 Sep 7.


The macrophage scavenger receptor 1 gene (MSR1) was recently identified as a candidate susceptibility gene for hereditary prostate cancer and as a risk factor for sporadic prostate cancer. To confirm these findings, we screened MSR1 for germline mutations among individuals with familial prostate cancer and tested gene variants for associations in both sporadic and familial prostate cancer. Our results do not support MSR1 as a risk factor for prostate cancer.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Genetic Variation
  • Germ-Line Mutation*
  • Humans
  • Male
  • Middle Aged
  • Molecular Sequence Data
  • Prostate-Specific Antigen / blood
  • Prostatic Neoplasms / epidemiology
  • Prostatic Neoplasms / genetics*
  • Receptors, Immunologic / genetics*
  • Receptors, Scavenger
  • Reference Values
  • Risk Factors
  • Scavenger Receptors, Class A


  • MSR1 protein, human
  • Receptors, Immunologic
  • Receptors, Scavenger
  • Scavenger Receptors, Class A
  • Prostate-Specific Antigen

Associated data

  • RefSeq/NM_138715