Membrane-associated CD40L and sCD40L in atherothrombotic disease

Thromb Haemost. 2003 Sep;90(3):377-84. doi: 10.1160/TH03-05-0268.

Abstract

Recent data suggests that CD40L is involved in the pathogenesis of atherothrombotic disease. This review will focus on the history of CD40L, its role in platelet-mediated pathogenesis of atherothrombotic disease, its association to clinical syndromes and procedures, and its role in determining plaque rupture.

Publication types

  • Review

MeSH terms

  • Arterial Occlusive Diseases / blood
  • Arterial Occlusive Diseases / etiology*
  • Arterial Occlusive Diseases / pathology
  • CD40 Ligand / blood
  • CD40 Ligand / metabolism
  • CD40 Ligand / physiology*
  • Humans
  • Matrix Metalloproteinases / metabolism
  • Platelet Membrane Glycoproteins / metabolism
  • Platelet Membrane Glycoproteins / physiology
  • Signal Transduction
  • Solubility
  • Thrombosis / blood
  • Thrombosis / etiology*
  • Thrombosis / pathology

Substances

  • Platelet Membrane Glycoproteins
  • CD40 Ligand
  • Matrix Metalloproteinases