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. 2003 Aug;33(4):443-8.
doi: 10.1023/a:1025019030121.

Lower Cortisol and Higher ACTH Levels in Individuals With Autism


Lower Cortisol and Higher ACTH Levels in Individuals With Autism

Jasna Marinović Curin et al. J Autism Dev Disord. .


Blood concentrations of pituitary hormones adrenocorticotropin (ACTH), prolactin, growth hormone, and adrenal hormone-cortisol were measured in 36 autistic and 27 control individuals. Individuals with autism had significantly lower serum concentrations of cortisol (p < 10(-6)), and significantly higher concentrations of ACTH (p = 0.002) than control age- and sex-matched subjects. Also, prolactin concentrations in autistic patients with epilepsy were significantly higher when compared with normal subjects. The observed hormonal changes may indicate dysfunction of the hypothalamo-pituitary-adrenal axis in individuals with autism.

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    1. J Autism Dev Disord. 1995 Dec;25(6):641-54 - PubMed
    1. Am J Psychiatry. 1997 Jun;154(6):726-35 - PubMed
    1. Pediatrics. 1991 May;87(5 Pt 2):791-6 - PubMed
    1. J Affect Disord. 2000 Jul;59(1):71-6 - PubMed
    1. Dis Nerv Syst. 1969 Sep;30(9):627-32 - PubMed

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