Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 375 (Pt 3), 503-15

Multifaceted Roles of Beta-Arrestins in the Regulation of Seven-Membrane-Spanning Receptor Trafficking and Signalling

Affiliations
Review

Multifaceted Roles of Beta-Arrestins in the Regulation of Seven-Membrane-Spanning Receptor Trafficking and Signalling

Sudha K Shenoy et al. Biochem J.

Abstract

Beta-arrestins are cytosolic proteins that bind to activated and phosphorylated G-protein-coupled receptors [7MSRs (seven-membrane-spanning receptors)] and uncouple them from G-protein-mediated second messenger signalling pathways. The binding of beta-arrestins to 7MSRs also leads to new signals via activation of MAPKs (mitogen-activated protein kinases) such as JNK3 (c-Jun N-terminal kinase 3), ERK1/2 (extracellular-signal-regulated kinase 1/2) and p38 MAPKs. By binding to endocytic proteins [clathrin, AP2 (adapter protein 2), NSF (N -ethylmaleimide-sensitive fusion protein) and ARF6 (ADP-ribosylation factor 6)], beta-arrestins also serve as adapters to link the receptors to the cellular trafficking machinery. Agonist-promoted ubiquitination of beta-arrestins is a prerequisite for their role in receptor internalization, as well as a determinant of the differing trafficking patterns of distinct classes of receptors. Recently, beta-arrestins have also been implicated as playing novel roles in cellular chemotaxis and apoptosis. By virtue of their ability to bind, in a stimulus-dependent fashion, to 7MSRs as well as to different classes of cellular proteins, beta-arrestins serve as versatile adapter proteins that regulate the signalling and trafficking of the receptors.

Similar articles

See all similar articles

Cited by 113 PubMed Central articles

See all "Cited by" articles

References

    1. J Biol Chem. 1993 Aug 15;268(23):16879-82 - PubMed
    1. J Biol Chem. 1994 Jan 28;269(4):2790-5 - PubMed
    1. J Biol Chem. 1994 Feb 11;269(6):4613-9 - PubMed
    1. J Biol Chem. 1994 Nov 11;269(45):27791-4 - PubMed
    1. J Biol Chem. 1995 Jan 13;270(2):720-31 - PubMed

Publication types

Feedback