Obesity favors surgical and infectious complications after renal transplantation

Transplant Proc. 2003 Aug;35(5):1762-3. doi: 10.1016/s0041-1345(03)00718-8.

Abstract

The prevalence of obesity is increasing in the renal transplant population. There are controversial data with respect to posttransplant outcome. We performed a study comparing the incidence of surgical and infectious complications among 40 obese patients (body mass index [BMI] pretransplant > or =30 kg/m2) versus a matched nonobese control group (BMI <30 kg/m2) transplanted at our center between June 1989 and March 2001.

Results: There were no differences in patient demographic variables (mean age, gender, cause of renal failure, or percentage of diabetes or hepatitis C virus infection). Donor age, HLA mismatching, sensitization, cold ischemia time, and immunosuppressive regimen were similar in both groups. The mean pretransplant BMI in obese and nonobese patients was 34.1+/-4.0 versus 23.00+/-2.73 kg/m2 (P<.01). The obese group showed a higher incidence of delayed graft function (30% versus 5%, P<.05) and wound infections (12.5%) posttransplant with similar incidences of wound dehiscence, perigraft collections, and graft function at the end of follow up.

Publication types

  • Comparative Study

MeSH terms

  • Body Mass Index
  • Body Weight
  • Diabetes Mellitus / epidemiology
  • Diabetic Nephropathies / surgery
  • Female
  • Humans
  • Incidence
  • Infections / epidemiology*
  • Intraoperative Complications / epidemiology*
  • Kidney Transplantation / adverse effects*
  • Male
  • Middle Aged
  • Obesity / complications*
  • Prevalence
  • Reference Values
  • Retrospective Studies