Colour coding in the primate retina: diverse cell types and cone-specific circuitry

Curr Opin Neurobiol. 2003 Aug;13(4):421-7. doi: 10.1016/s0959-4388(03)00103-x.

Abstract

How is the trichromatic cone mosaic of Old World primates sampled by retinal circuits to create wavelength opponency? Red-green (L versus M cone) opponency appears to be mediated largely by the segregation of L versus M cone signals to the centre versus the surround of the midget ganglion cell receptive field, implying a complex cone type-specific wiring, the basis of which remains mysterious. Blue-yellow (S versus L+M cone) opponency is mediated by a growing family of low-density ganglion types that receive either excitatory or inhibitory input from S cones. Thus, the retinal circuits that underlie colour signalling in primates may be both more complex and more diverse then previously appreciated.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Color Perception / physiology*
  • Humans
  • Nerve Net / cytology
  • Nerve Net / physiology*
  • Primates
  • Retina / cytology
  • Retina / physiology*
  • Retinal Cone Photoreceptor Cells / cytology
  • Retinal Cone Photoreceptor Cells / physiology*
  • Visual Pathways / cytology
  • Visual Pathways / physiology*