Antithrombin III (AT3) polymorphism in the marsupial Monodelphis domestica: identification and genetics

Biochem Genet. 1992 Dec;30(11-12):591-601.


Antithrombin III polymorphism was observed in the gray short-tailed opossum, Monodelphis domestica, by either one-dimensional polyacrylamide gel electrophoresis (PAGE; pH 7.9), two-dimensional PAGE (agarose, pH 5.4; 12% T, pH 7.9), or isoelectric focusing (pH 4.2-4.9) followed by immunoblotting with rabbit antiserum to human antithrombin III. Family studies demonstrated an inheritance of three codominant autosomal alleles, AT3A, AT3B, and AT3C, and a population study revealed frequencies of 0.70, 0.10, and 0.20, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Animals
  • Antithrombin III / genetics*
  • Antithrombin III / isolation & purification
  • Blood Protein Electrophoresis
  • Brazil
  • Electrophoresis, Gel, Two-Dimensional
  • Electrophoresis, Polyacrylamide Gel
  • Gene Frequency
  • Immunoblotting
  • Isoelectric Focusing
  • Opossums / blood
  • Opossums / genetics*
  • Polymorphism, Genetic*


  • Antithrombin III