Repetitive elements in genomes of parasitic protozoa

Microbiol Mol Biol Rev. 2003 Sep;67(3):360-75, table of contents. doi: 10.1128/mmbr.67.3.360-375.2003.

Abstract

Repetitive DNA elements have been a part of the genomic fauna of eukaryotes perhaps since their very beginnings. Millions of years of coevolution have given repeats central roles in chromosome maintenance and genetic modulation. Here we review the genomes of parasitic protozoa in the context of the current understanding of repetitive elements. Particular reference is made to repeats in five medically important species with ongoing or completed genome sequencing projects: Plasmodium falciparum, Leishmania major, Trypanosoma brucei, Trypanosoma cruzi, and Giardia lamblia. These organisms are used to illustrate five thematic classes of repeats with different structures and genomic locations. We discuss how these repeat classes may interact with parasitic life-style and also how they can be used as experimental tools. The story which emerges is one of opportunism and upheaval which have been employed to add genetic diversity and genomic flexibility.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Centromere / genetics
  • Eukaryota / genetics*
  • Genes, Protozoan / genetics*
  • Genome, Protozoan*
  • Giardia lamblia / genetics
  • Leishmania major / genetics
  • Plasmodium falciparum / genetics
  • Repetitive Sequences, Nucleic Acid / genetics*
  • Retroelements / genetics
  • Telomere / genetics
  • Trypanosoma brucei brucei / genetics
  • Trypanosoma cruzi / genetics

Substances

  • Retroelements