Abstract
Vinylated and allylated chrysin analogues were prepared as congeners of prenylated flavonoids and evaluated their anti-inflammatory activity. 8-Substituted chrysin analogues were prepared from 2'-hydroxy-3'-iodo-4',6'-dimethoxyacetophenone in 3 steps. 3-Allylated chrysin analogues were prepared from chrysin in 3 steps. Synthesized chrysin analogues (4, 5 and 8) showed moderate inhibitory activities of PGE2 production from LPS-induced RAW 264.7 cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Allyl Compounds / chemical synthesis*
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Allyl Compounds / chemistry
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Allyl Compounds / pharmacology
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Animals
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Cell Line
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Cyclooxygenase 2
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Dinoprostone / antagonists & inhibitors*
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Flavonoids / chemical synthesis*
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Flavonoids / chemistry
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Flavonoids / pharmacology
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Isoenzymes / metabolism
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Mice
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Molecular Structure
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Prostaglandin-Endoperoxide Synthases / metabolism
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Structure-Activity Relationship
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Vinyl Compounds / chemical synthesis*
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Vinyl Compounds / chemistry
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Vinyl Compounds / pharmacology
Substances
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Allyl Compounds
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Flavonoids
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Isoenzymes
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Vinyl Compounds
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chrysin
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Cyclooxygenase 2
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Prostaglandin-Endoperoxide Synthases
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Dinoprostone