DSA: a new internal standard for NMR studies in aqueous solution

Org Lett. 2003 Sep 18;5(19):3511-3. doi: 10.1021/ol035347w.

Abstract

[structure: see text] The widely used internal standard for NMR studies in aqueous solution DSS (sodium 4,4-dimethyl-4-silapentane-1-sulfonate) can interact with cationic peptides, diminishing its value for such studies. This paper introduces DSA (4,4-dimethyl-4-silapentane-1-ammonium trifluoroacetate) as a new internal standard that does not suffer from this problem.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acids, Aromatic / chemistry
  • Amino Acids, Basic / chemistry
  • Fluoroacetates*
  • Magnetic Resonance Spectroscopy / methods*
  • Organosilicon Compounds / chemical synthesis*
  • Peptides / analysis
  • Peptides / chemistry
  • Reference Standards
  • Reproducibility of Results
  • Solutions / chemistry
  • Trifluoroacetic Acid / chemical synthesis*
  • Water / chemistry

Substances

  • 4,4-dimethyl-4-silapentane-1-ammonium trifluoroacetate
  • Amino Acids, Aromatic
  • Amino Acids, Basic
  • Fluoroacetates
  • Organosilicon Compounds
  • Peptides
  • Solutions
  • Water
  • Trifluoroacetic Acid