The purpose of this study was to examine the effects of Panax ginseng extract (PGE) on lipid metabolism in humans by measuring cholesterol, malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT). Serum total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL) and plasma MDA levels were decreased by administration of PGE for 8 weeks (6g per day), however, high density lipoprotein (HDL) was increased. Those results suggest that hypolipidemic effect of PGE is associated with a decrease in TC, TG, LDL, MDA levels and an increase in HDL. These findings support scientific claims that ginseng has the hypolipidemic potential. Administration of PGE increased SOD and CAT activities while decreased MDA level indicating that antioxidant potential of PGE might induce hypolipidemic effect as one of action mechanism.